The Vitamin D - Vitamin D Receptor Axis Alleviates LPS - induced Acute Pulmonary Edema by Reducing Angiopoietin - 2

ABSTRACT

The mechanism by which the Vitamin D - Vitamin D Receptor Axis alleviates LPS - induced Acute Pulmonary Edema remains unclear, and the disruption of tight junctions may be one of the mechanisms. In this study, both animal and cell models were employed to investigate the possible reasons for the alleviation of acute pulmonary edema by vitamin D. The results demonstrated that VD indeed reduced the wet - to - dry ratio of the lungs, inflammatory cell infiltration, pathological symptoms, and the signaling pathways related to pyroptosis. Finally, it was discovered that VD alleviates pulmonary edema by inhibiting the disruption of tight junctions caused by Ang2 rather than directly antagonizing LPS.