Clinical study on Mulberry water decoction in treatment of xerophthalmia of menopausal females

ABSTRACT

Objective: To investigate the clinical effect of Mulberry water decoction on xerophthalmia of menopausal females. Method: This study was a prospective random controlled trial. Forty-eight menopausal females diagnosed with xerophthalmia (aged from 45 to 55) were randomly divided into in two groups: group A the control group (vitamin c tablets) (n = 24) and group B the Mulberry water decoction group (n = 24). Both groups were treated with Forte Eye Drops. All patients were detected at 7d, 1month, 2month, before and after treatment to evaluate OSDI, four tear film indicators and tear protein. Variance analysis and differential analysis on sample average or median were made on both groups before and after treatment, observe the status under confocal microscope before and after treatment under. Result: There weas no significant difference in detection index between both groups before treatment. Group A after treatment for 7 d, 1 month, OSDI has changed, there were statistical differences（all P＜ 0.05）. After treatment for 2 months, OSDI, BUT, SIT, tears river height and FL were no significant changes, there were no statistically significant differences (P > 0.05). At 7d, 1 month, 2 month after treatment, B group of patients OSDI, BUT, SIT, tears river height and FL were improved, there were statistical differences（all P＜0.05）. TP, LF, LZM, sIgA all have different degree of change in group A and B, but there were not statistically differences（all P＞ 0.05）. The results corneal confocal microscopy showed that after 2mo treatment of group A, the nuclei of squamous epithelial cell is light, the border is high reflection. After 2 months treatment of Group B, corneal epithelial layer of mild scale highly reflective of change. At 6 weeks after treatment, the mean number of corneal basal cells and inflammatory cells in group A were ( 4489 ± 215)mm-2 and ( 311 ± 102 )mm-2，respectively， which in group B were ( 3315 ± 212) mm-2 and ( 39 ± 14)mm-2 , respectively，there were statistical differences between two groups ( all P ＜0.05). After 6 weeks treatment, there were no change of corneal nerve bending 37 and less density in group A while the nerve fiber bending and density decreased significantly in group B ，there were statistical differences between two groups ( all P ＜0.05)．Conclusion: Mulberry water decoction can effectively improve symposiums and signs of xerophthalmia among menopausal females and thus showing clinical significance to some extent. its cellular structure, gene expression, and immunologic